The Society of Cosmetic Scientists promotes education, research and collaboration to advance the science of cosmetics

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10 March 2016 - Medal Lecture

'Translational science and ageing skin'

Christopher Griffiths MD FRCP FMedSci (Professor of Dermatology, The University of Manchester)


Skin ageing is driven by intrinsic and extrinsic factors. Intrinsic or chronological ageing is a slow, subtle process leading to changes that affect cutaneous function more than they do appearance whereas sun-induced extrinsic ageing (photoageing) produces the majority of clinical features, such as wrinkles, associated with age. An understanding of the mechanisms underlying skin ageing, whether they are biochemical or immunological, is driving a discovery-to-care research agenda whereby new discoveries about prevention and/or repair can be translated rapidly into better skin care.

Fibrillin and other extracellular matrix molecules are still the key targets for successful topical anti-ageing approaches coupled with increasing awareness of: the differences in skin structure between individuals of different geographical ancestries and; the role of the immune system and inflammation in skin ageing.  Intercellular and intracellular signalling processes between epidermis and dermis will become targets for anti-ageing products. Inter-individual differences will be further exploited through stratified medicine approaches leading to personalised skincare.



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