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Thursday 8 May 2014 - RDG Ireland

RDG IRELAND EVENT

Thursday 8 May 2014

Venue: The Science Gallery (The Naughton Institute, Pearse Street, Trinity College, Dublin / nearby Pearse Station

 

AGING, ANTI-OXIDANTS AND BEYOND: NEED FOR A NEW PARADIGM

Prof Gérard Friedlander

Synopsis

This is a common view that aging may result, at least in part, from oxidant stress. According to this view, reactive oxygen species (ROS), generated by cell metabolism, induce DNA damages, protein carbonylation and misfolding, lipid peroxidation, and mitochondrial dysfunction.

However, recent studies performed in model organisms, such as C. Elegans, challenged this dogma by showing that a moderate increase in ROS generation results in extension of life span. Moreover, in this unique long-living mammal, the naked mole-rat, which lives ten times longer than a mouse with a similar weight/size, ROS generation is quite high, together with DNA damage, lipid peroxidation and protein carbonylation.

These data raise the question of whether the oxidant stress is a cause or a consequence of aging and urge us to revisit the cause-effect relationship between aging and the oxidant stress, and to propose alternatives to the anti-oxidant strategies for combating aging.


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